Paper Details

PJB-2023-535

Effect of Moringa oleifera leaf and seed extracts on the synthesis of zinc nanoparticles and their antibacterial ability and cytotoxi

Jehan S. Albrahim, Jumanah S. Alsoaimi, Ahoud M. Altaher, Reem N. Almulayfi and Najood F. Alharbi
Abstract


Moringa belongs to the Moringaceae family, composed of 13 species, 7 of which are tropical and 4 of which are subtropical. This plant is a veritable health fount of nutrients, including minerals, vitamins, and amino acids. It contains vitamin A as well as vitamin C. Polyphenols, calcium, iron, copper, zinc, magnesium, folic acid, and beta-carotene are present. Moringa oleifera is often considered in many medical applications. In traditional medicine, it has been used to cure various types of bacterial and fungal infections. Among the scurvy, cholesterol, tumors, cholera, asthma, spasmodic, and anxiety are treated by the same methods. Also, the seed is suitable for water filtration via normal coagulation in the water. Several characterization approaches were employed to analyze ZnO nanoparticles. The purpose of this study was to conduct anticancer activity and antibacterial investigations in Moringa oleifera plants in Saudi Arabia using zinc nanoparticle production. In this study, we have used the nutrient and Mueller Hinton agar as well as zinc chloride (ZnCl2). The preparation of culture, bacteria, and extracts, as well the synthesis of zinc nanoparticles and anticancerous activities, were performed. The results of the current investigation support their potential to treat Staphylococcus aureus, Bacillus subtilis, and Escherichia coli with their antibacterial properties. The antibacterial activity of the plant extracts results showed the highest inhibition zone in S. aureus with M. oleifera seed extract in the amount of 27mm, and in E. coli with the extract of M. oleifera seeds, similar to the extract of M. oleifera leaves in S. aureus in the amount of 17.6 mm. Then B. subtilis with an inhibition zone in extract M. oleifera seeds was 10.8mm and followed by the same bacteria in the extract of M. oleifera leaves (9.3mm). The other results carried out with ZnCl2NPs in the first experiment showed the highest inhibition in B. subtilis in the extract of M. oleifera leaves ZnCl2NPs (27.93mm), followed by the extract of M. oleifera leaves ZnCl2NPs in E. coli (27.6mm). Then, S. aureus in the extract M. oleifera leaves ZnCl2NPs (26.53mm) and B. subtilis in the extract M. oleifera seeds ZnCl2NPs (22.06mm). Our study concludes that Moringa Oleifera leaf extract can be utilized to make nanoparticles and can also be used for cancer treatment. The mineral salt can be used, and zinc nanoparticles are also acceptable. Antimicrobial and anticancer nanoparticles have been confirmed once they are used

To Cite this article: Albrahim, J.S., J.S. Alsoaimi, A.M. Altaher, R.N. Almulayfi and N.F. Alharbi. 2025. Effect of Moringa oleifera leaf and seed extracts on the synthesis of zinc nanoparticles and their antibacterial ability and cytotoxicity. Pak. J. Bot., 57(1): DOI: http://dx.doi.org/10.30848/PJB2025-1(5)  
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