Traditional medicine has been practiced in Algeria for centuries, thanks to the richness and diversity of its flora, which encompasses a veritable phylogenetic library of over 3,000 species from various plant families. The aim of our study is to explore people's interactions with medicinal plants through an ethnobotanical approach and document the traditional knowledge of medicinal flora in the steppe environments of the Brezina region. During the 2021-2022 period, ethnobotanical field surveys were conducted with medicinal plant informants using 300 questionnaires. We selected 15 stations and interviewed the same number of participants in each stratum (20). The collected data was then entered into a database and statistically processed and analyzed using Microsoft Office Excel 2020. The study's results reveal that leaves are the most commonly used part of medicinal plants. Infusion is the preferred method of preparation in most medicinal recipes. The majority of users of medicinal plants are married. These plants are primarily utilized to treat respiratory issues. The survey recorded 29 medicinal plant species across 16 botanical families, highlighting significant floristic diversity. The leading families included Lamiaceae at 32.7%, followed by Apiaceae at 12.11%, Amaranthaceae at 11.46%, and Asteraceae at 7.29%. The plant's usage value ranges from 0.03 to 0.97. The following species exhibited the highest usage value (UV) levels for treating disorders in the Brezina region: Salvia rosmarinus (0.97), Mentha spicata (0.94), Ephedra foeminea (0.92), Mentha pulegium (0.91), Arthrophytum scoparium (0.88), Peganum harmala (0.84), Ziziphus lotus (0.81), Pimpinella anisum (0.81), and Thymus vulgaris (0.76). Lamiaceae and Apiaceae are often prominent due to their fragrant and medicinal attributes. The primary application of these medicinal plants is in the treatment of respiratory disorders. Among the 29 species identified in the studied area, nine are more commonly utilised in traditional phytotherapy by the local community.