PJB-2020-257
Antibacterial, antitumor activity and phytochemical studies of methanolic extract of (Catharnthus roseus) (Linn.) G. Don.
Komal Riaz, Zarrin Fatima Rizvi, Sajjad Hyder and Robina Rashed
Abstract
The therapeutic role of plant materials is getting more attention due to fewer or no side effects as compared to synthetic chemical based medicines. Catharanthus roseus (L.) G Don is an important medicinal plant belonging to apocynaceae family, which serves as a reservoir of various important phytochemicals. We have investigated the antibacterial, antitumor activity, and phytochemical study of methanol-based leaf extracts of C. roseus. The qualitative phytochemical analysis showed the presence of flavonoids, terpenoids, glycosides, anthraquinone, tannins, proteins, carbohydrates, saponins, and alkaloids in the methanol based leaf extract of C. roseus. Extract of C. roseus also displayed DPPH radical scavenging activity at all the tested concentrations. Antibacterial potential of C. roseus was evaluated against a few selected human pathogens viz., M. luteus, S. aureus, and E. coli in replicated experiments. The methanolic extract of C. roseus displayed maximum inhibition (17.7 ± 0.88mm) and (17.3 ± 0.67mm) against M. luteus and E. coli and minimum inhibition (13 ± 1.15mm) against S. aureus. Methanolic leaf extract of C. roseus also displayed antitumor activity In vitro. The results have revealed that methanolic extract of C. roseus can be used as a source of potential antibacterial products
To Cite this article:
Riaz, K., Z.F. Rizvi, S. Hyder and R. Rashed. 2021. Antibacterial, antitumor activity and phytochemical studies of methanolic extract of (Catharnthus roseus) (Linn.) G. Don. Pak. J. Bot., 53(6): DOI: http://dx.doi.org/10.30848/PJB2021-6(3)
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