PJB-2024-49
In vitro anti-inflammatory, anticancer and antimicrobial activity of Annona reticulata peel and pulp extracts – a comparative study
Kalist Shagirtha, Mani Divya, Manoj Kumar Srinivasan, Saravanan Alamelu, Kamalesh Balakumar Venkatesan, Megala Sivaprakasam, Chellasamy Panneerselvam, Mohammed Ali Alshehri, Laila A. Alshuraym and Samy Sayed
Abstract
Recently, research has been focused on the pharmacological properties of natural compounds as potential therapeutic agents. Annona reticulata a member of family Annonaceae is a source for both industrial and medicinal products. It has a therapeutic effect, including anthelmintic, antipyretic, anti-inflammatory, cytotoxic and wound-healing properties. Phytochemicals such flavonoids, phenols, alkaloids, steroids, tannins, and glycosides are widely distributed in it. The present study compared the antibacterial, anti-inflammatory, and anticancer activities of Annona reticulata (red custard apple) fruit pulp and peel extracts of fruits. The anti-inflammatory activity of pulp and peel extract of Annona reticulata was determined by inhibition of albumin denaturation and membrane lysis assay. The anticancer activity was tested against the MCF-7 using the MTT assays. The antibacterial properties against Pseudomonas aeruginosa and Proteus mirabilis was studied by disc diffusion method. The findings showed that the fruit pulp extract had more potential for anti-inflammatory, antibacterial, and anticancer action than the peel extract chosen for testing. Based on our findings, we suggested that Annona reticulata pulp serve as a valuable source of ingredients for both the culinary and pharmaceutical industries
To Cite this article:
Shagirtha, K., M. Divya, M.K. Srinivasan, S. Alamelu, K.B. Venkatesan, M. Sivaprakasam, C. Panneerselvam, M.A. Alshehri, L.A. Alshuraym and S. Sayed. 2025. In vitro anti-inflammatory, anticancer and antimicrobial activity of Annona reticulata peel and pulp extracts – a comparative study. Pak. J. Bot., 57(3): DOI: http://dx.doi.org/10.30848/PJB2025-3(26)
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